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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
27.27
Human Site:
S168
Identified Species:
50
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
S168
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
Chimpanzee
Pan troglodytes
XP_514624
382
43769
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
S270
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
Dog
Lupus familis
XP_542986
665
76981
S206
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
S169
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
Rat
Rattus norvegicus
XP_230789
677
77635
S224
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
S159
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
Frog
Xenopus laevis
Q6INN8
632
72730
S165
S
H
N
R
F
E
H
S
I
G
V
G
Y
L
A
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
V158
G
Y
L
A
G
C
L
V
K
A
L
N
E
R
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
G154
G
E
F
A
K
R
N
G
S
R
F
K
H
E
D
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
A157
C
Y
L
A
G
E
F
A
R
S
L
Q
R
N
Q
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
A68
V
S
G
V
S
G
A
A
H
M
V
Y
P
G
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
V64
R
E
L
K
Q
L
G
V
T
N
M
V
Y
P
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
0
100
100
N.A.
100
100
N.A.
N.A.
100
93.3
0
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
100
0
100
100
N.A.
100
100
N.A.
N.A.
100
100
13.3
N.A.
N.A.
N.A.
13.3
26.6
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
24
0
0
8
16
0
8
0
0
0
0
62
% A
% Cys:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% D
% Glu:
0
16
0
0
0
62
0
0
0
0
0
0
8
8
0
% E
% Phe:
0
0
8
0
54
0
8
0
0
0
8
0
0
0
0
% F
% Gly:
16
0
8
0
16
8
8
8
0
54
0
54
0
8
8
% G
% His:
0
54
0
0
0
0
54
0
8
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
8
0
0
0
8
0
0
8
0
0
0
% K
% Leu:
0
0
24
0
0
8
8
0
47
0
16
0
0
54
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% M
% Asn:
0
0
54
0
0
0
8
0
0
8
0
8
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
16
% Q
% Arg:
8
0
0
54
0
8
0
0
8
8
0
0
8
8
0
% R
% Ser:
54
8
0
0
8
0
0
54
8
8
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% T
% Val:
8
0
0
8
0
0
0
16
0
0
62
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
16
0
0
0
0
0
0
0
0
0
8
62
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _